MR & CT Perfusion Imaging: Clinical Applications and Theoretical Principles

The long-awaited first edition of MR and CT Perfusion and Pharmacokinetic Imaging: Clinical Applications and Theory is a welcome new resource for healthcare professionals involved in the rapidly evolving field of perfusion technology. Using MRI and CT scanning procedures, perfusion imaging is being used with increasing frequency to aid the diagnostic process in a wide spectrum of pathologies, including ischemia, cancer, inflammation and many more, throughout the entire human body.
This is the first text of its kind to comprehensively address the technical and clinical aspects of perfusion imaging, used in both MRI and CT.

Features

• The first text to include both MRI and CT in perfusion imaging studies and highlight their parallels as well as the strengths and weaknesses of each modality
• Overarching approach spanning from data acquisition to postprocessing and clinical data interpretation
• Includes real-life scenarios depicting the use of perfusion in actual patient cases
• Contains hundreds of MRI and CT scans that portray anatomy, variants, and pathology
• Provides key learning points and protocol suggestions for numerous clinical questions
• Each chapter unites international leaders in the field to convey most up-to-date knowledge

Now with the print edition, enjoy the bundled interactive eBook edition, offering tablet, smartphone, or online access to:

• Complete content with enhanced navigation
• A powerful search that pulls results from content in the book, your notes, and even the web
• Cross-linked pages, references, and more for easy navigation
• Highlighting tool for easier reference of key content throughout the text
• Ability to take and share notes with friends and colleagues
• Quick reference tabbing to save your favorite content for future use

Foreword - "MR and CT Perfusion and Pharmacokinetic Imaging: Clinical Applications and Theory"
Robert Grossman
Foreword (Body Imaging)
Geoffrey Rubin
1 Introduction
Roland Bammer
2 Primer on CT Physics & Hardware
J. Hsieh
3 CT Image Reconstruction Basics
Joachim Hornegger, Andreas Maier, Markus Kowarschik
4 Dose Considerations in CT Perfusion
Lifeng Yu, Shuai Leng, Lance J. Phillips, Dawn Banghart, Cynthia H McCollough
5 Clinical Applications and Theoretical Principles: Primer on Physics of MR & Hardware
Maxim Zaitsev, Michael Markl
6 MR Image Reconstruction
Jeffrey Tsao, Vikas Gulani
7 Noise Considerations in CT and MRI
G. Glover, N. Pelc
8 MR Relaxation Theory and Exchange Processes in the Presence of Contrast Agents
Joel R. Garbow, Joseph J. H. Ackerman
9 MR and CT Contrast Agents for Perfusion Imaging and Regulatory Issues
Henrik S. Thomsen, Peter Dawson, Michael F. Tweedle
10 Contrast Agent Safety and Nephrogenic Systemic Fibrosis
Moazzem Kazi, Georg Bongartz
Martin R. Prince
11 Bolus Gymnastics: Flow Rates, Molarity, and Other Tricks
D. Fleischmann, R. Bammer
12 The Blood Brain Barrier and Microcirculation and Their Modulation by Disease and Drug Related Effects
B. Zlokovic, D. Kleinfeld
13 Acquisition Schemes for CT Perfusion
R. Fahrig, A. Fieselmann, M. Straka
14 Xe- Enhanced CT Perfusion Measurements
Andrew P Carlson, Howard Yonas
15 Susceptibility Contrast in Tissues: Gradient-Echoes vs. Spin-Echoes
Jerrold L. Boxerman, Matthias van Osch, Kathleen M. Schmainda
16 MR Pulse Sequences for DSC
R. Bammer, R. Newbould, H. Schmiedeskamp, J. van den Brink
17 Vessel Size Imaging
Valerij G. Kiselev, Heiko Schmiedeskamp
18 Oxygen Extraction Fraction (OEF) Imaging
Weili Lin, Hongyu An, Thomas Christen
19 Basic Principles of ASL – CASL VS. PASL
Yufen Chen, John A. Detre
20 Readout and Background Suppression Techniques
David Thomas, Matthias Guenther, Xavier Golay
21 Pseudo-continuous ASL
D. Alsop, A. Shankaranarayan, David C. Alsop, Ajit Shankaranarayanan
22 Confounding Effects in ASL
Danny JJ Wang, María A. Fernández-Seara, Hanzhang Lu
23 Flow Territory Mapping: Region Selective Arterial Spin Labeling
M.J.P. van Osch, Matthias Guenther, Eric C. Wong
24 Velocity Selective ASL
Eric C. Wong, Lawrence R. Frank
25 Keys to Robust ASL in the Clinical and Research Environment
David C. Alsop, Jeroen Hendrikse
26 “Pick your Poison”: The ASL Shopper’s Guide or Which Method for Which Application?
H. Lu, M. Guenther, X. Golay, T. Liu
27 The Basic Principles of Dynamic Contrast Enhanced Magnetic Resonance Imaging
Julio Cárdenas-Rodríguez, Xia Li, Jennifer G. Whisenant, Stephanie Barnes, Rudolf Stollberger, John C. Gore, Thomas E. Yankeelov
28 Acquisition and Reconstruction Methods for DCE and Factors Affecting Measurement Accuracy
R. Stollberger, B. Hargreaves
29 How does CT relate to MR
R. Bammer
30 Convolution Model
Peter Gall, T.-Y. Lee, Roland Bammer
31 Practical Aspects of Deconvolution
Prof. Fernando Calamante, Matus Straka, Lisa Willats
32 Arterial Input Function and Venous Output Function
Soren Christensen, Matus Straka, Ting Lee
33 The Bookend Technique and Other Scaling Techniques
Timothy J. Carroll, Jessy J. Mouannes-Srour
34 The Effects of Contrast Agent Extravasation Perfusion Parameter Maps
Derived from Dynamic Susceptibility Contrast MRI
Kathleen M. Schmainda, Eric S. Paulson, Jerrold L. Boxerman
35 Slope Method
U. Haberland, E. Klotz
36 Pharmacokinetic models for DCE-CT and DCE-MRI
Steven Sourbron, Ting-Yim Lee
37 Blood Flow Quantitation With ASL
Laura M. Parkes, Hanzhang Lu, Esben T. Petersen
38 Perfusion confusion: what is perfusion and what do we measure?
Richard B. Buxton
39 DSC: Calibration between Sites and Comparability
J. Alger, M. van Osch, T. Niendorf, P. Schaefer, K. Kudo, R. Bammer
40 CTP: Calibration between Sites and Comparability
B. Zussmann, V. Goh, P. Schaefer, K. Kudo, M. Wintermark
41 ASL Calibration between sites and Comparability
Tom Liu, Thijs van Osch, Matthias Guenther, Xavier Golay
42 DCE: Calibration between Sites and Comparability
J.L. Evelhoch, G. Zahlmann, S. Gupta, E.J. Jackson
43 Basal Blood Flow to Different Organs and Tissues
R. Bammer
44 MR and CT Contrast Agent Dosage Lookup Table (0.5x, 1.0x, 1.5x, ... 3.0x dose) vs. Bodyweight
R. Bammer
45 General Patient Dressing and Power Injector Configurations
L. Molvin, T. Nelson
46 DSC: Acquisition and Enhancement Protocols
R. Bammer, P. Schaefer, J. Alger, H. Rowley, T. Niendorf
47 ASL: Acquisition Protocols
Y. Jung, G. Zaharchuk, J. Hendrikse, J. Maldjian
48 CTP: Acquisition and Enhancement Protocols
R. Bammer, K. Arkoth, V. Goh, T. Christian, P. Schaefer
49 DCE: Acquisition and Enhancement Protocols
G. Zahlmann, S. Gupta, J.L. Eveloch, E.J. Jackson
50 Cerebrovascular Anatomy and Regional Blood Supply
Robert Vollmann, Michael Augustin
51 Normal and Abnormal Physiology of Cerebral Blood Flow
Dr Andrew Bivard, A/Prof Mark Parsons
52 Acute Stroke: Intra-Arterial and Intra-Venous Treatment Options
T. Jovin, M. Marks, N. Schwarz
53 Perfusion Profiles For Favorable And Unfavorable Outcome
Lansberg, Mishra Christensen Campbell
54 Collateral Flow, Luxury Perfusion, and Vasospasm: Clinical applications and theoretical principles
Mateo Calderon-Arnulphi, Peter D Schellinger, David S Liebeskind
55 The role of multimodal brain imaging in clinical stroke trials
Bruce CV Campbell, Geoffrey A Donnan, Stephen M Davis
56 Lacunar Stroke and Microangiopathy
Brian D. Zipser, Bhavya Rehani, Pamela W. Schaefer
57 Perfusion and DCE Imaging In Hemorrhage
Didem Aksoy, Andrea Kassner, Jason Hom, Karen Hirsch, Christine Wijman, Chitra Venkatasubramanian
58 Perfusion Imaging in Chronic Occlusive Disease of Intracranial Vessels and Vascular Reserve Testing
Jeroen Hendrikse, Greg Zaharchuk
59 Perfusion In Chronic Carotid Artery Disease
Nolan S. Hartkamp, Reinoud P.H. Bokkers, Jeroen Hendrikse
60 TIA and Perfusion Imaging
Shyam Prabhakaran, Jonathan Kleinman, Greg Zaharchuk, Jean-Marc Olivot
61 ASL in AVMs
Ronald L. Wolf, Jeffrey M. Pollock
62 Perfusion in DAVFs
S.A. Amukotuwa, R. Bammer
63 Migraine and Seizures
Hongwu Zeng, Christian La, Veena A. Nair, Vivek Prabhakaran, Howard A. Rowley
64 Pediatric Stroke and Congenital Disease
Seena Dehkharghani, Nilesh K. Desai
65 The tumor vasculature: structure and function
Janice A. Nagy, Amjad Husain, Shou-Ching Jaminet, Ann M. Dvorak, Harold F. Dvorak
66 RECIST and WHO criteria
Syed Mahmood, Saleha Sajid
67 De Novo Brain Tumor Evaluation: Use of Individual and Combined DSC, DCE, and ASL for Diagnosis and Differentiation
Jalal B. Andre, Pia C. Sundgren, Mark S. Shiroishi, Meng Law
68 Predicting Prognosis, Therapy Selection, Guidance & Treatment Monitoring
Mark S. Shiroishi, Jesse G.A. Jones, Jalal B. Andre, Marco Essig, P. C. Sundgren, Paul E. Kim Meng Law
69 Contrast Enhancement: Differentiating Tumor Recurrence from Non-Neoplastic Tissue Following Intervention (Surgery, Chemotherapy, Radiotherapy)
Jalal B. Andre, James Fink, Mark S. Shiroishi, Pia C Sundgren, Sarah Foster, Alexander Lerner, Michael T. Booker
70 Vessel Size Imaging to Predict Tumor Grade and Angiogenesis
K. Schmainda, T.T. Batchelor, J.L. Boxerman, V. Kiselev
71 Head and Neck Cancer
S. Mukherji, G. Shah, Z. Rumboldt, A. Shukla-Dave, Yongang Lu, H. Poptani
72 Female Pelvis
T Barrett, AB Gill, E Sala
73 Lung Cancer
Vicky Goh, Peter Hoskin
74 Breast Cancer
B. Daniel
75 Prostate Cancer
Olivier Rouvierre
76 Perfusion Imaging in Liver and Pancreas
Se Hyung Kim, Dow-Mu Koh, Jürgen K. Willmann
77 Renal Tumors
Mark A. Rosen, Stephen M. Keefe, Priti Lal, William M. F. Lee
78 Gastrointestinal Imaging
Nyree Griffin, Lee Grant, Vicky Goh
79 Clinical Applications of DCE-MRI in Musculoskeletal Tumors
June S. Taylor, Wilburn E. Reddick, Robert J. Canter
80 Oncology Drug Development
Ed Ashton
81 Myocardial Perfusion and Permeability
Rozemarijn Vliegenthart, Michael Jerosch-Herold, Krishna Nayak, Tim Leiner,
Sven Plein
82 Dementia and Degenerative Diseases
Norbert Schuff
83 Perfusion in Pharmacological Imaging
Fernando O Zelaya, Maria Fernández-Seara, Kevin Black, Steven CR Williams,
Mitul A Mehta
84 Perfusion and DCE Imaging in White Matter Disease
Matilde Inglese, Jens Würfel
Glyn Johnson
85 Pulmonary Perfusion Heterogeneity: Gravity, Hypoxia, Inflammation
E. Hoffman
86 Cerebral Perfusion Studies in Substance Abuse and Dependence
Santosh Yadav, Thomas Ernst, Linda Chang
87 Perfusion and DCE Imaging to Study Renal Function
D. Gratton-Smith
88 ASL for Functional Neuroimaging
Thomas T. Liu
89 Vascular Response To Hypoxia And Hypercapnia
Daniel P. Bulte, Molly G. Bright, Franklyn A. Howe, Douglas R. Corfield
90 Retinal and Choroidal Blood Flow
Timothy Q Duong, Eric R Muir
91 Vascular-space-occupancy (VASO) MRI
Jun Hua, Ying Cheng, Peter C. M. van Zijl
92 CT Perfusion Imaging: How Did It All Start?
Leon Axel
93 The Early Days of MR DSC Perfusion Imaging
A. Villringer
94 The Early History of ASL MRI: 1992-2000
John A. Detre
95 The Early Days of Modelling Contrast Agent Kinetics
Paul S Tofts